Loss of TET2 impairs endothelial angiogenesis via downregulating STAT3 target genes.

Yefei ShiBo LiXinru HuangWenxin KouMing ZhaiYanxi ZengShuangjie YouQing YuYifan ZhaoJianhui ZhuangWenhui PengWeixia Jian

Published in: Cell & bioscience (2023)

Our study suggests that the deficiency of TET2 in endothelial cells impairs angiogenesis via suppression of the STAT3 signaling pathway. These findings give solid evidence for TET2 to be a therapeutic alternative for ischemic diseases.

Keyphrases

endothelial cells
signaling pathway
vascular endothelial growth factor
high glucose
cell proliferation
pi k akt
genome wide
gene expression
replacement therapy
transcription factor
brain injury