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TIM-4 increases the proportion of CD4 + CD25 + FOXP3 + regulatory T cells in the pancreatic ductal adenocarcinoma microenvironment by inhibiting IL-6 secretion.

Ziyao WangZerong XieYu MouRuiman GengChen ChenNeng-Wen Ke
Published in: Cancer medicine (2024)
TIM-4 has the potential to be an immunotherapeutic target or to improve the efficacy of chemotherapy for PDAC.
Keyphrases
  • regulatory t cells
  • dendritic cells
  • stem cells
  • signaling pathway
  • locally advanced
  • human health
  • squamous cell carcinoma
  • immune response
  • rectal cancer
  • chemotherapy induced