Trametinib inhibits lymphatic vessel invasion of bone in a mouse model of Gorham-Stout disease.

Published in: Journal of vascular anomalies (2023)

mice. These findings further support the testing of MEK inhibitors in patients with GSD and other RAS pathway-driven complex lymphatic anomalies with bone involvement.

Keyphrases

mouse model
bone mineral density
lymph node
soft tissue
bone loss
wild type
bone regeneration
cell migration
high fat diet induced
body composition
adipose tissue
skeletal muscle