Ectopic ACTH-producing neuroendocrine tumor occurring with large recurrent metastatic pheochromocytoma: a case report.

Fumi SaishoujiSarie MaedaHideaki HamadaNoriko KimuraAi TamanoiSaiko NishidaMasaji SakaguchiMotoyuki IgataKiho YokooFumi KawakamiEiichi ArakiTatsuya Kondo

Published in: BMC endocrine disorders (2022)

We experienced a case of severe ectopic ACTH producing the largest reported recurrent malignant left PCC with liver metastases that presented positive feedback loops in the ACTH/cortisol and catecholamine/cortisol axes. Clinicians should be aware of the paradoxical response of ACTH on metyrapone treatment and possible steroid-induced catecholamine crisis.

Keyphrases

liver metastases
public health
squamous cell carcinoma
small cell lung cancer
drug induced
high glucose
diabetic rats
oxidative stress
endothelial cells
replacement therapy