SIRT1 ameliorates oxidative stress induced neural cell death and is down-regulated in Parkinson's disease.

Preeti SinghPeter S HansonChristopher M Morris

Published in: BMC neuroscience (2017)

These findings suggests a negative effect of oxidative stress in neurodegenerative disorders and possibly explain the reduced activity of SIRT1 in neurodegenerative disorders. Our study shows that SIRT1 is a pro-survival protein that is downregulated under cellular stress.

Keyphrases

oxidative stress
ischemia reperfusion injury
cell death
diabetic rats
dna damage
induced apoptosis
transcription factor
protein protein
binding protein
amino acid