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Identification of a marine-derived sesquiterpenoid, Compound-8, that inhibits tumour necrosis factor-induced cell death by blocking complex II assembly.

Yuan HeTingting YangJiao LiKaiying LiChun-Lin ZhuangMeng ZhangRan LiYaxing ZhaoQianqian SongMengyuan JiangShuichun MaoXin-Gang SongYufeng GuoXuran LiFei TanSiriporn JitkaewWen ZhangZhenyu Cai
Published in: British journal of pharmacology (2024)
A marine fungus-derived sesquiterpenoid, Cpd-8, inhibits TNF receptor superfamily-induced cell death, both in vitro and in vivo. This study not only provides a useful research tool to investigate the regulatory mechanisms of TNF-induced cell death but also identifies a promising lead compound for future drug development.
Keyphrases
  • cell death
  • high glucose
  • diabetic rats
  • rheumatoid arthritis
  • cell cycle arrest
  • drug induced
  • gene expression
  • oxidative stress
  • current status