In vivo compartmental kinetics of Plasmodium falciparum histidine-rich protein II in the blood of humans and in BALB/c mice infected with a transgenic Plasmodium berghei parasite expressing histidine-rich protein II.
Kristin E PotiAmanda E BalabanPriya PalTamaki KobayashiDaniel E GoldbergPhotini SinnisDavid J SullivanPublished in: Malaria journal (2019)
The data suggest that persistence of PfHRP2 is due to slower clearance of protein from the RBC fraction of the whole blood. This appears to be a result of the presence PfHRP2 in previously infected, pitted cells, as opposed to PfHRP2 binding naïve RBCs in circulation post-treatment. The results thus confirm that the extended duration of RDT positivity after parasite clearance is likely due to pitted, once-infected RBCs that remain positive for PfHRP2.
Keyphrases
- plasmodium falciparum
- protein protein
- binding protein
- induced apoptosis
- amino acid
- type diabetes
- small molecule
- metabolic syndrome
- oxidative stress
- big data
- electronic health record
- transcription factor
- adipose tissue
- machine learning
- skeletal muscle
- cell proliferation
- insulin resistance
- endoplasmic reticulum stress
- life cycle