Tanshinone IIA reduces SW837 colorectal cancer cell viability via the promotion of mitochondrial fission by activating JNK-Mff signaling pathways.

Sayilaxi JieensinueHong ZhuGuangcheng LiKeli DongMeiting LiangYayue Li

Published in: BMC cell biology (2018)

Altogether, our results identified mitochondrial fission as a new potential target to control cancer viability, mobility and proliferation. Furthermore, our findings demonstrate that Tan IIA is an effective drug to treat colorectal cancer by activating JNK-Mff-mitochondrial fission pathways.

Keyphrases

signaling pathway
oxidative stress
induced apoptosis
pi k akt
epithelial mesenchymal transition
papillary thyroid
cell death
risk assessment
squamous cell
cell proliferation
lymph node metastasis
climate change