Mutational status of NRAS, KRAS, and PTPN11 genes is associated with genetic/cytogenetic features in children with B-precursor acute lymphoblastic leukemia.

Der-Cherng LiangShih-Hsiang ChenHsi-Che LiuChao-Ping YangTing-Chi YehTang-Her JaingIou-Jih HungJen-Yin HouTung-Huei LinChun-Hui LinLee-Yung Shih

Published in: Pediatric blood & cancer (2017)

Our study showed that the frequency of KRAS mutations in Taiwan was significantly higher than that reported in Caucasians. The occurrence of RAS pathway mutations was associated with recurrent genetic/cytogenetic abnormalities in pediatric B-precursor ALL.

Keyphrases

wild type
acute lymphoblastic leukemia
genome wide
young adults
copy number
risk assessment
dna methylation
gene expression