Hypoxia-induced autophagy drives colorectal cancer initiation and progression by activating the PRKC/PKC-EZR (ezrin) pathway.

Komal Qureshi-BaigDiana KuhnElodie ViryVitaly I PozdeevMartine SchmitzFabien RodriguezPit UllmannEric KoncinaMartin NurmikSonia FrasquilhoPetr V NazarovNikolaus ZuegelMarc BoulmontYervand KarapetyanLaurent AntunesDaniel ValMichel MittelbronnBassam JanjiSerge HaanElisabeth Letellier

Published in: Autophagy (2019)

ATG: autophagy related; BECN1: beclin 1; BNIP3: BCL2 interacting protein 3; BNIP3L: BCL2 interacting protein 3 like; CQ: chloroquine; CSC: cancer stem cells; CRC: colorectal cancer; HIF1A/HIF-1α: hypoxia inducible factor 1 subunit alpha; MAP1LC3/LC3: microtubule associated protein 1 light chain 3; PRKC/PKC: protein kinase C; SQSTM1/p62: sequestosome 1; TICs: tumor-initiating cells.

Keyphrases

protein kinase
induced apoptosis
signaling pathway
cancer stem cells
endoplasmic reticulum stress
cell death
cell cycle arrest
oxidative stress
protein protein
endothelial cells
mass spectrometry
amino acid
binding protein
small molecule
cell proliferation
tandem mass spectrometry