Impaired renal HCO3 - secretion in CFTR deficient mice causes metabolic alkalosis during chronic base-loading.

Peder BergSamuel L SvendsenThi Thuy Linh HoangHelle A PraetoriusMads V SorensenJens Leipziger

Published in: Acta physiologica (Oxford, England) (2020)

CFTR KO mice develop metabolic alkalosis during a chronic base-load because they are unable to sufficiently elevate renal HCO3 - excretion. This can be explained by markedly reduced pendrin function in the absence of CFTR.

Keyphrases

cystic fibrosis
type diabetes
wild type