Synthesis of Fluorescent Au Nanocrystals-Silica Hybrid Nanocomposite (FLASH) with Enhanced Optical Features for Bioimaging and Photodynamic Activity.
Taeshik KimHongje JangSeongchan KimJong-Hwan LeeSung-Yon KimNoo Li JeonJoon Myong SongDal-Hee MinPublished in: Langmuir : the ACS journal of surfaces and colloids (2017)
Fluorescent Au nanocrystals (AuNCs)-silica hybrid nanocomposite (FLASH) was synthesized by co-condensation of surface-modified AuNCs. Present FLASH nanocomposite exhibited four times the enhanced photoluminescence and photocatalytic activity compared to single nanocrystals. On the basis of these enhanced optical features, we successfully demonstrated in vitro fluorescence bioimaging of introduced FLASH to human cervical cancer cell line (HeLa). Beyond the confirmation of photocatalytic activity from the photodegradation of methylene blue as a model compound, the regional selective photodynamic therapy of HeLa cells under UV irradiation was also presented. Taken together the enhanced optical features and further potential in theranostic applications, we expect that the present FLASH can be a promising tool for nanobiotechnology field.
Keyphrases
- quantum dots
- reduced graphene oxide
- energy transfer
- visible light
- sensitive detection
- photodynamic therapy
- high resolution
- living cells
- cell cycle arrest
- gold nanoparticles
- room temperature
- highly efficient
- induced apoptosis
- endothelial cells
- fluorescent probe
- mass spectrometry
- drug delivery
- cell death
- cancer therapy
- cell proliferation
- signaling pathway
- oxidative stress
- climate change
- human health
- radiation induced
- carbon nanotubes