Association of clonal hematopoiesis and mosaic chromosomal alterations with solid malignancy incidence and mortality.

Pinkal M DesaiYing ZhouJustin GrenetSamuel K HandelmanCynthia M CrispinoLaura N TarbayEric A WhitselGail RobozAna BaracMichael HonigbergAlexander BickGarnet AndersonJean Wactawski-WendeYasminka A Jakubek SwartzlanderJason BaconJustin WongXiaolong MaPaul ScheetZichan LiPashtoon KasiRoss PrenticePaul AuerJoAnn E MansonAlexander ReinerMichael S Simon

Published in: Cancer (2024)

CHIP and mCA (CF >5%) were associated with higher breast cancer risk and colorectal cancer mortality individually. These data could inform on novel pathways that impact cancer risk and lead to better risk stratification.

Keyphrases

breast cancer risk
risk factors
cardiovascular events
cystic fibrosis
high throughput
type diabetes
circulating tumor cells
gene expression
cardiovascular disease
machine learning
coronary artery disease
dna methylation
data analysis