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The impact of fluphenazine withdrawal: a mirror-image study.

S MeehanS MoranA RainfordC McDonaldB Hallahan
Published in: Irish journal of psychological medicine (2024)
The withdrawal of fluphenazine was associated with increased relapse rate in individuals previously demonstrating stability of their psychotic disorder. While acknowledging the limitation of small sample size, preliminary evidence from this study suggests that treatment with the first-generation antipsychotic (FGA) flupenthixol was associated with a lower risk of relapse compared to SGAs. Reasons for this lower risk of relapse are not fully clear but could be related to dopamine hypersensitivity with this treatment change.
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