Histologic and Transcriptional Evidence of Subclinical Synovial Inflammation in Patients With Rheumatoid Arthritis in Clinical Remission.
Dana E OrangePhaedra AgiusEdward F DiCarloSerene Z MirzaTania PannelliniJackie SzymonifkaCaroline S JiangMark P FiggieMayu O FrankWilliam H RobinsonLaura T DonlinCristina RozoEllen M GravalleseVivian P BykerkSusan M GoodmanPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2019)
Thirty-one percent of patients with low clinical disease activity exhibited histologic evidence of subclinical synovitis, which was associated with increased CRP and anti-CCP levels. Our findings suggest that synovial gene expression signatures of clinical synovitis are present in patients with subclinical synovitis.