Evaluation of Voriconazole CYP2C19 Phenotype-Guided Dose Adjustments by Physiologically Based Pharmacokinetic Modeling.
Pablo ZubiaurLisa A KnellerDolores OchoaGina P Mejía-AbrilMiriam Saiz-RodriguezAlberto M BorobiaDora KollerIrene García GarcíaMarcos Navares-GómezGeorg HempelFrancisco Abad-SantosPublished in: Clinical pharmacokinetics (2021)
The prescription of voriconazole in clinical practice should be personalized according to the CYP2C19 phenotype, followed by therapeutic drug monitoring of plasma concentrations to guide dose adjustment.
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