High-level ceftazidime-avibactam resistance in Escherichia coli conferred by the novel plasmid-mediated beta-lactamase CMY-185 variant.

William C ShropshireBradley T EndresJovan BorjanSamuel L AitkenWilliam C BachmanChristi L McElhenyAyesha KhanMicah M BhattiPranoti SaharasbhojaneAkito KawaiRyan K ShieldsSamuel A ShelburneYohei Doi

Published in: bioRxiv : the preprint server for biology (2023)

associated with a novel CMY variant. Unlike other AmpC enzymes, CMY-185 appears to require an additional substitution on top of N346Y to confer CZA resistance.

Keyphrases

escherichia coli
klebsiella pneumoniae
gram negative
multidrug resistant
biofilm formation
crispr cas