Notch-1 and Notch-3 Mediate Hypoxia-Induced Activation of Synovial Fibroblasts in Rheumatoid Arthritis.

Jianhai ChenWenxiang ChengJian LiYan WangJingqin ChenXin ShenAiling SuDonghao GanLiqing KeGang LiuJietao LinLiang LiXueling BaiPeng Zhang

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2021)

This study identified a functional link between HIF-1α, Notch-1, and Notch-3 signaling in regulating activation of RASFs and the processes involved in the pathogenesis of RA.

Keyphrases

rheumatoid arthritis
cell proliferation
disease activity
ankylosing spondylitis
interstitial lung disease
extracellular matrix
systemic sclerosis