Immediate histologic correlation in women with atypical squamous cells of undetermined significance cytology and positive high-risk HPV: A retrospective review of 6000 cases in a large academic women's hospital.
Huina ZhangDinesh PradhanTiannan WangDayne AshmanJonee MatskoChengquan ZhaoPublished in: Cancer cytopathology (2020)
These hrHPV testing methods revealed low CIN2+ detection rates in women with ASC-US/hrHPV+ but demonstrated different patterns when using age-stratified analyses. The high rate of CIN2+ detection in women aged <25 years by the Cervista and Aptima testing platforms, but not the HC2 platform, suggest that continual investigation of FDA-approved clinical hrHPV testing-especially large-scale, long-term, prospective studies-is needed to evaluate the best options for management of ASC-US/hrHPV+ in this age group.
Keyphrases
- high grade
- polycystic ovary syndrome
- cervical cancer screening
- induced apoptosis
- loop mediated isothermal amplification
- pregnancy outcomes
- healthcare
- label free
- low grade
- high throughput
- type diabetes
- emergency department
- single cell
- cell cycle arrest
- insulin resistance
- metabolic syndrome
- cell death
- fine needle aspiration
- pregnant women
- breast cancer risk
- acute care
- oxidative stress
- medical students