Interaction between tumor cell TNFR2 and monocyte membrane-bound TNF-α triggers tumorigenic inflammation in neuroblastoma.

Julie A TomolonisXin Xu Kshiti H DholakiaChunchao ZhangLinjie GuoAmy N CourtneySiyue WangJulien BalzeauGabriel A BarragánGengwen TianErica J Di PierroLeonid S Metelitsa

Published in: Journal for immunotherapy of cancer (2023)

We have described a novel mechanism of tumor-promoting inflammation in NB that is strongly associated with patient outcome and could be targeted with therapy.

Keyphrases

oxidative stress
rheumatoid arthritis
single cell
cell therapy
dendritic cells
endothelial cells
cancer therapy
stem cells
immune response
peripheral blood
bone marrow