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Interaction between tumor cell TNFR2 and monocyte membrane-bound TNF-α triggers tumorigenic inflammation in neuroblastoma.

Julie A TomolonisXin XuKshiti H DholakiaChunchao ZhangLinjie GuoAmy N CourtneySiyue WangJulien BalzeauGabriel A BarragánGengwen TianErica J Di PierroLeonid S Metelitsa
Published in: Journal for immunotherapy of cancer (2023)
We have described a novel mechanism of tumor-promoting inflammation in NB that is strongly associated with patient outcome and could be targeted with therapy.
Keyphrases
  • oxidative stress
  • rheumatoid arthritis
  • single cell
  • cell therapy
  • dendritic cells
  • endothelial cells
  • cancer therapy
  • stem cells
  • immune response
  • peripheral blood
  • bone marrow