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Mismatch binding ligand upregulated back-splicing reaction producing circular RNA in a cellular model.

Lu NiTakeshi YamadaAsako MurataKazuhiko Nakatani
Published in: Chemical communications (Cambridge, England) (2022)
Circular RNA (circRNA) is a covalently closed single-stranded RNA produced from pre-mRNAs via back-splicing reaction, an alternative form of splicing. Here, we show naphthyridine carbamate dimer (NCD) upregulating the production of a circRNA from a pre-mRNA containing NCD-binding site UGGAA/UGGAA in cells, demonstrating the feasibility of small-molecule mediated circRNA production.
Keyphrases
  • small molecule
  • binding protein
  • induced apoptosis
  • cell cycle arrest
  • nucleic acid
  • protein protein
  • cell death
  • oxidative stress
  • dna binding
  • electron transfer
  • cell proliferation
  • pi k akt