Temporal Dynamics of β-Amyloid Accumulation in Aging and Alzheimer Disease.
William J JagustSusan M Landaunull nullPublished in: Neurology (2021)
Lowering brain Aβ must be accomplished early in the evolution of AD. Transitions of PET scans from Aβ- to Aβ+ should be predictable, and it is reasonable to expect that lowering rates of Aβ even in early stages could produce clinically significant benefits.