Rotavirus group A genotype circulation patterns across Kenya before and after nationwide vaccine introduction, 2010-2018.

Mike J MwangaBetty E OworJohn B OchiengMwanajuma H NgamaBilly OgwelClayton OnyangoJane JumaRegina NjeruElijah GicheruGrieven P OtienoSammy KhagayiCharles N AgotiGodfrey M BigogoRichard OmoreO Yaw AddoSeheri MapasekaJacqueline E TateUmesh D ParasharElizabeth HunspergerJennifer R VeraniRobert F BreimanD James Nokes

Published in: BMC infectious diseases (2020)

Genotype prevalence varied from before to after vaccine introduction. Such observations emphasize the need for long-term surveillance to monitor vaccine impact. These changes may represent natural secular variation or possible immuno-epidemiological changes arising from the introduction of the vaccine. Full genome sequencing could provide insights into post-vaccine evolutionary pressures and antigenic diversity.

Keyphrases

public health
risk factors
gene expression
single cell