Bestrophin3 Deficiency in Vascular Smooth Muscle Cells Activates MEKK2/3-MAPK Signaling to Trigger Spontaneous Aortic Dissection.

Ting-Ting ZhangQing-Qing LeiJie HeXin GuanXin ZhangYing HuangZi-Yue ZhouRui-Xin FanTing WangChen-Xi LiJin-Yan ShangZhuo-Miao LinWan-Li PengLi-Kai XiaYu-Ling HeChuan-Ying HongJing-Song OuRui-Ping PangXiao-Ping Fan Hui Huang Jia-Guo Zhou

Published in: Circulation (2023)

These findings unveil a critical role of Best3 in regulating smooth muscle cell phenotypic switch and aortic structural integrity through controlling MEKK2/3 degradation. Best3-MEKK2/3 signaling represents a novel therapeutic target for AD.

Keyphrases

aortic dissection
smooth muscle
vascular smooth muscle cells
angiotensin ii
signaling pathway
cell therapy
single cell
oxidative stress
pulmonary artery
mesenchymal stem cells
coronary artery
bone marrow
smoking cessation