Astragaloside IV Improves the Barrier Damage in Diabetic Glomerular Endothelial Cells Stimulated by High Glucose and High Insulin.
Tingting ZhaoJiaye TianTiancheng XuXi ZhangQian XiangJianfeng XiongDing-Kun GuiYou-Hua XuPublished in: Evidence-based complementary and alternative medicine : eCAM (2022)
We found in the present study that AS-IV can preserve filtration barrier integrity in glomerular endothelial cells under diabetic settings, its effects on increasing the cell energy metabolism and cell viability, inhibiting inflammation and oxidative stress damage, and enhancing tight junction between cells play a role in it; and the intracellular signaling pathway AKT-GSK modulated the above function. Our present finding supplied a new understanding towards development of DN and provided an alternative method on ameliorating DN.
Keyphrases
- high glucose
- endothelial cells
- signaling pathway
- oxidative stress
- induced apoptosis
- pi k akt
- type diabetes
- cell cycle arrest
- epithelial mesenchymal transition
- diabetic rats
- ischemia reperfusion injury
- wound healing
- dna damage
- cell proliferation
- single cell
- endoplasmic reticulum stress
- vascular endothelial growth factor
- glycemic control
- cell therapy
- blood brain barrier
- metabolic syndrome