Sex-specific genetic influence on thyroid-stimulating hormone and free thyroxine levels, and interactions between measurements: KNHANES 2013-2015.

Young Ki LeeDong Yeob ShinHyejung ShinEun Jig Lee

Published in: PloS one (2018)

The genetic influences on individual TSH levels were more prominent in females than in males. In addition, female-specific pleiotropy between TSH and fT4 might be a clue that this stronger genetic influences in females would mainly affect thyroid function per se, rather than other TSH-related factors that do not primarily trigger the negative feedback loop between TSH and fT4.

Keyphrases

genome wide
copy number
transcription factor
gene expression
dna methylation