Increased Capillary Permeability in Heart Induces Diastolic Dysfunction Independently of Inflammation, Fibrosis, or Cardiomyocyte Dysfunction.
Alice AbelanetMarion CamoinSebastien RubinPauline BougaranValentin DelobelMathieu PernotIsabelle ForfarCéline Guilbeau-FrugierCéline GalèsMarie-Lise BatsMarie-Ange RenaultPascale DufourcqThierry CouffinhalMuralidharan SargurupremrajPublished in: Arteriosclerosis, thrombosis, and vascular biology (2022)
An increase of endothelial permeability is responsible for mediating diastolic dysfunction pathophysiology and for aggravating detrimental effects of a high-fat diet on cardiac inflammation and metabolism.