Identification of a novel TNRC18-RARA fusion in acute promyelocytic leukemia lacking t(15;17)(q24;q12)/PML-RARA.

Zheng WangLijun WenLing ZhangXiaoyu XuXiaoqian ChenLi YaoMan WangZhen ShenGuangquan MoYao WangDewan ZhaoWei CaiJingzhi ShenXiaomeng ChiYi XuZhao ZengJinlan PanChanggeng RuanDepei WuZhilin JiaSuning Chen

Published in: Molecular carcinogenesis (2021)

Acute promyelocytic leukemia (APL) is a unique disease entity in acute myeloid leukemia, characterized by PML-RARA fusion gene, which is generated by chromosomal translocation t(15;17)(q24;q21). We identified TNRC18-RARA as novel RARA fusion in resembling APL. Our study highlights the importance of combining multiple molecular techniques to characterize and optimally manage APL lacking classic t(15;17)(q24;q12)/PML-RARA fusion.

Keyphrases

liver failure
acute myeloid leukemia
bone marrow
respiratory failure
copy number
aortic dissection
dna methylation
intensive care unit
hepatitis b virus
single molecule
acute respiratory distress syndrome
genome wide analysis