Metabolic Health Status Contributes to Transcriptome Alternation in Human Visceral Adipose Tissue During Obesity.

Qiuzhong ZhouZhenzhen FuYingyun GongVeerabrahma Pratap SeshachalamJia LiYizhe MaHui LiangWei GuanShibo LinSujoy GhoshLei Sun Hongwen Zhou

Published in: Obesity (Silver Spring, Md.) (2020)

This study reveals not only that BMI plays an important role in determining the gene expression profile in visceral adipose tissue but also that a metabolically healthy condition is associated with a less inflammatory transcriptional change during obesity.

Keyphrases

insulin resistance
adipose tissue
high fat diet induced
high fat diet
metabolic syndrome
skeletal muscle
genome wide
type diabetes
endothelial cells
gene expression
weight gain
weight loss
body mass index
oxidative stress
transcription factor
rna seq
dna methylation
induced pluripotent stem cells