LncRNA FENDRR with m6A RNA methylation regulates hypoxia-induced pulmonary artery endothelial cell pyroptosis by mediating DRP1 DNA methylation.
Xiaoying WangQian LiSiyu HeJune BaiCui MaLixin ZhangXiaoyu GuanHao YuanYiying LiXiangrui ZhuJian MeiFeng GaoXiaoying WangPublished in: Molecular medicine (Cambridge, Mass.) (2022)
In summary, our results demonstrated that m6A-induced decay of FENDRR promotes HPAEC pyroptosis by regulating DRP1 promoter methylation and thereby provides a novel potential target for HPH therapy.
Keyphrases
- dna methylation
- pulmonary artery
- genome wide
- coronary artery
- high glucose
- pulmonary hypertension
- pulmonary arterial hypertension
- endothelial cells
- nlrp inflammasome
- gene expression
- diabetic rats
- long non coding rna
- copy number
- drug induced
- transcription factor
- long noncoding rna
- oxidative stress
- human health
- stem cells
- mesenchymal stem cells
- risk assessment
- bone marrow
- vascular endothelial growth factor