Attenuation of neurovirulence of chikungunya virus by a single amino acid mutation in viral E2 envelope protein.
Huixin ChenPatchara PhuektesLi Sze YeoYi Hao WongRegina Ching Hua LeeBowen YiXinjun HouSen LiuYu CaiJustin Jang Hann ChuPublished in: Journal of biomedical science (2024)
These findings highlight the attenuating effects of the E2-G55R mutation on CHIKV pathogenicity and neurovirulence and emphasize the importance of monitoring this mutation in natural infections.