HLA Genotyping in Synovial Sarcoma: Identifying HLA-A*02 and Its Association with Clinical Outcome.

Evan RosenbaumKenneth P SeierChaitanya BandlamudiMark DicksonMrinal GounderMary L KeohanPing ChiCiara KellySujana MovvaBenjamin A NacevNoemi SimeoneMark DonoghueEmily K SlotkinLi-Xuan QinCristina R AntonescuWilliam D TapSandra P D'Angelo

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2020)

Targeted gene panels like MSK-IMPACT may accurately report HLA type and identify loss of somatic HLA alleles. In a multivariable model, HLA-A*02 eligibility was not significantly associated with OS in patients with metastatic SS.

Keyphrases

genome wide
copy number
high throughput
single cell
genetic diversity