Identification and therapeutic modulation of a pro-inflammatory subset of disease-associated-microglia in Alzheimer's disease.

Srikant RangarajuEric B DammerSyed Ali RazaPriyadharshini RathakrishnanHailian XiaoTianwen GaoDuc M DuongMichael W PenningtonJames J LahNicholas T SeyfriedAllan I Levey

Published in: Molecular neurodegeneration (2018)

We provide a predictive transcriptomic framework of microglial activation in neurodegeneration that can guide pre-clinical studies to characterize and therapeutically modulate neuroinflammation in AD.

Keyphrases

inflammatory response
lipopolysaccharide induced
neuropathic pain
traumatic brain injury
cognitive decline
single cell
spinal cord injury
rna seq
cerebral ischemia