Beneficial Effect of Genistein on Diabetes-Induced Brain Damage in the ob/ob Mouse Model.

Rong-Zi LiXiao-Wen DingThangiah GeethaLayla Al-NakkashTom L BroderickJeganathan Ramesh Babu

Published in: Drug design, development and therapy (2020)

The results of our study indicate the beneficial effects of genistein in the obese diabetic mouse brain, including improving brain insulin signaling, increasing neurotrophic support, and alleviating Alzheimer's disease-related pathology.

Keyphrases

type diabetes
mouse model
resting state
white matter
glycemic control
cardiovascular disease
adipose tissue
functional connectivity
oxidative stress
cerebral ischemia
diabetic rats
high glucose
metabolic syndrome
drug induced
cognitive decline
multiple sclerosis
skeletal muscle
bariatric surgery
blood brain barrier