Traumatic injury results in prolonged circulation of ultralarge von Willebrand factor and a reduction in ADAMTS13 activity.

Mitchell R DyerWilliam E PlautzMargaret V RagniWyeth AlexanderShannon HaldemanJason L SperryFrancis X GuyetteBrian S ZuckerbraunMarian A Rollins-RavalJay S Raval Matthew D Nealnull null

Published in: Transfusion (2020)

Traumatic injury is associated with acute coagulopathy that is characterized by increased UL-VWF multimers and reduction in ADAMTS13, which correlates with blood loss, transfusion requirement, and injury severity. These findings suggest the potential for future trials targeting ADAMTS13 repletion to enhance clearance of VWF multimers.

Keyphrases

spinal cord injury
current status
drug induced
cancer therapy
climate change
risk assessment
extracorporeal membrane oxygenation