Associations of plasma clusterin and Alzheimer's disease-related MRI markers in adults at mid-life: The CARDIA Brain MRI sub-study.
Thaddeus HaightR Nick BryanOsorio MeirellesRussell TracyMyriam FornageMelissa A RichardIlya M NasrallahKristine YaffeDavid R JacobsCora LewisPamela SchreinerStephen SidneyChristos DavatzikosLenore J LaunerPublished in: PloS one (2018)
In middle-aged adults unselected for AD, plasma clusterin was associated with lower volume of the entorhinal cortex, an area that atrophies early in AD. Clusterin could be informative as part of a multi-component preclinical marker for AD.