Case report of meningoencephalitis associated with SARS-CoV-2 infection showing a decrease in idiopathic focal cerebral blood flow.
Kazumasa SekiguchiKosuke MatsuzonoTakafumi MashikoReiji KoideShigeru FujimotoPublished in: SAGE open medical case reports (2024)
Some neurological complications are associated with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A 74-year-old man was diagnosed with infection by SARS-CoV-2. Eighteen days after SARS-CoV-2 infection, he developed disturbed consciousness and aseptic meningoencephalitis. An analysis of cerebrospinal flood revealed an elevated cell count (184/μL) and protein level (260 mg/dL). Cranial magnetic resonance imaging showed no abnormalities. By contrast, 123 I-N-isopropyl-p-iodoamphetamine single-photon emission computed tomography showed a significant decrease in cerebral blood flow (CBF) in the left parietal and occipital lobes. He died suddenly 3 months after being transferred to a rehabilitation clinic without any clear cause of death. The SARS-CoV-2 infection can cause aseptic meningoencephalitis with a distinctive decrease in CBF pattern without magnetic resonance image abnormality or intracranial artery stenosis.
Keyphrases
- respiratory syndrome coronavirus
- cerebral blood flow
- sars cov
- magnetic resonance
- magnetic resonance imaging
- computed tomography
- contrast enhanced
- case report
- single cell
- coronavirus disease
- primary care
- positron emission tomography
- deep learning
- working memory
- risk factors
- cell therapy
- protein protein
- dual energy
- stem cells
- peripheral blood
- cerebral ischemia
- mesenchymal stem cells
- small molecule
- optic nerve
- blood brain barrier