MicroRNA copy number alterations in the malignant transformation of pleomorphic adenoma to carcinoma ex pleomorphic adenoma.

Talita de Carvalho KimuraJoão Figueira ScariniLuccas LavarezeLuiz Paulo KowalskiCláudia Malheiros Coutinho-CamilloAna Cristina Victorino KrepischiErika Said Abu EgalAlbina AltemaniFernanda Viviane Mariano

Published in: Head & neck (2024)

This study was the first to explore CNAs in miRNA-encoding genes in the PA-CXPA sequence. The findings suggest the involvement of numerous miRNA genes in CXPA development and progression by regulating oncogenic signaling pathways.

Keyphrases

copy number
genome wide
mitochondrial dna
dna methylation
signaling pathway
genome wide identification
bioinformatics analysis
transcription factor
epithelial mesenchymal transition
pi k akt
cell proliferation