STAT1- and NFAT-independent amplification of purinoceptor function integrates cellular senescence with interleukin-6 production in preadipocytes.
Yasser MajeedAisha Y MadaniAhmed I AltamimiRaphael CourjaretMuneera VakayilSamuel J FountainKhaled MachacaNayef A MazloumPublished in: British journal of pharmacology (2022)
We report a previously uncharacterized link between cellular senescence and purinergic signalling in preadipocytes and endothelial cancer cells, raising the possibility that up-regulated purinoceptors play key modulatory roles in senescence-associated conditions like obesity and cancer. There is potential for exploitation of specific purinoceptor antagonists as therapeutics in inflammatory disorders.
Keyphrases
- endothelial cells
- dna damage
- stress induced
- metabolic syndrome
- insulin resistance
- papillary thyroid
- type diabetes
- weight loss
- oxidative stress
- small molecule
- cell proliferation
- transcription factor
- nucleic acid
- high fat diet induced
- adipose tissue
- young adults
- skeletal muscle
- body mass index
- human health
- childhood cancer