The role of solute carrier (SLC) transporters in actinomycin D pharmacokinetics in paediatric cancer patients.

Hannah Yejin KimGareth J VealFanfan ZhouAlan V Boddy

Published in: European journal of clinical pharmacology (2018)

Transport of actinomycin D was mediated by OAT4 and PEPT2 in vitro. There was a lack of clinical significance of OAT4 and PEPT2 genotypes as predictors of actinomycin D disposition in paediatric cancer patients.

Keyphrases

intensive care unit
emergency department