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Nanoparticle curcumin ameliorates experimental colitis via modulation of gut microbiota and induction of regulatory T cells.

Masashi OhnoAtsushi NishidaYoshihiko SugitaniKyohei NishinoOsamu InatomiMitsushige SugimotoMasahiro KawaharaAkira Andoh
Published in: PloS one (2017)
Treatment with nanoparticle curcumin suppressed the development of DSS-induced colitis potentially via modulation of gut microbial structure. These responses were associated with induction of mucosal immune cells with regulatory properties. Nanoparticle curcumin is one of the promising candidates as a therapeutic option for the treatment of IBD.
Keyphrases
  • regulatory t cells
  • dendritic cells
  • ulcerative colitis
  • transcription factor
  • immune response
  • mouse model