Evaluation of Chitotriosidase and Neopterin as Biomarkers of Microvascular Complications in Patients with Type 1 Diabetes Mellitus.
Ancuța CutașCristina DruganGabriela RomanAdriana RusuCristina Sorina CătanăAndrei Achimaș-CadariuTudor C DruganPublished in: Diagnostics (Basel, Switzerland) (2021)
The chronic complications of diabetes mellitus (DM) are accompanied by inflammatory manifestations. Our study aimed to evaluate a possible association between the inflammatory status (reflected by serum chitotriosidase and neopterin) and the timely evolution and occurrence of chronic microvascular complications in patients with type 1 DM. This observational, cross-sectional study included 82 type 1 DM patients from the Centre for Diabetes, Nutrition and Metabolic Diseases, Cluj-Napoca, Romania. Our results demonstrated a link between the extent of inflammation, evaluated by the enzymatic activity of circulating chitotriosidase, and the onset of microvascular complications, especially diabetic neuropathy and retinopathy. Chitotriosidase enzymatic activity showed an ascending evolution over time. In non-smoking patients, the increase in chitotriosidase activity was correlated with the extent of microalbuminuria and the decline of glomerular filtration rate, while in smokers, only the presence of a positive correlation between chitotriosidase activity and disease progression was noticed. According to our results, the time span between the moment of diagnosis and the onset of microvascular complications was longer in non-smokers than in smokers. These results also imply that increased chitotriosidase activity may be a predictor of endothelial dysfunction in type 1 DM.
Keyphrases
- end stage renal disease
- risk factors
- smoking cessation
- oxidative stress
- ejection fraction
- newly diagnosed
- type diabetes
- glycemic control
- chronic kidney disease
- prognostic factors
- physical activity
- cardiovascular disease
- risk assessment
- coronary artery
- metabolic syndrome
- skeletal muscle
- patient reported outcomes
- patient reported
- weight loss
- pulmonary hypertension
- drug induced