CYP2R1 polymorphisms are important modulators of circulating 25-hydroxyvitamin D levels in elderly females with vitamin insufficiency, but not of the response to vitamin D supplementation.

Asma ArabiN Khoueiry-ZgheibZ AwadaR MahfouzL Al-ShaarM HoteitM RahmeR BaddouraG HalabiR SinghG El Hajj Fuleihan

Published in: Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA (2016)

This study showed a difference in 25(OH)D levels between CYP2R1 genotypes that equates a daily supplementation of 400-800 IU vitamin D, depending on genotype. It underscores possible important genetic contributions for the high prevalence of hypovitaminosis D in the Middle East.

Keyphrases

small molecule
physical activity
middle aged
gene expression
community dwelling
dna methylation