Risk estimation model for nonalcoholic fatty liver disease in the Japanese using multiple genetic markers.

Takahisa KawaguchiToshihide ShimaMasayuki MizunoYasuhide MitsumotoAtsushi UmemuraYoshihiro KanbaraSaiyu TanakaYoshio SumidaKohichiro YasuiMeiko TakahashiKeitaro MatsuoYoshito ItohKatsutoshi TokushigeEtsuko HashimotoKendo KiyosawaMasanori KawaguchiHiroyuki ItohHirofumi UtoYasuji KomorizonoKen ShirabeShiro TakamiToshinari TakamuraMiwa KawanakaRyo YamadaFumihiko MatsudaTakeshi Okanoue

Published in: PloS one (2018)

We demonstrated that NASH is genetically and clinically different from the other NAFLD subgroups. We also established risk-estimation models for NAFLD and NASH using multiple genetic markers. These models can be used to improve the accuracy of NAFLD diagnosis and to guide treatment decisions for patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
chronic kidney disease
genome wide
peritoneal dialysis
prognostic factors
copy number
dna methylation
smoking cessation
patient reported