The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis.
Ju-Sheng ZhengJian'an LuanEleni SofianopoulouStephen J SharpFelix R DayFumiaki ImamuraThomas E GundersenLuca A LottaIvonne SluijsIsobel D StewartRupal L ShahYvonne T van der SchouwEleanor WheelerEva ArdanazHeiner BoeingMiren DorronsoroChristina Catherine DahmNiki L DimouDouae El-FatouhiPaul W FranksGuy FagherazziSara GrioniJosé María Huerta CastañoAlicia K HeathLouise HansenMazda JenabPaula JakszynRudolf KaaksTilman KühnKay-Tee KhawNasser LaoualiGiovanna MasalaPeter M NilssonKim OvervadAnja W OlsenSalvatore PanicoJ Ramón QuirósOlov RolandssonMiguel Rodríguez BarrancoCarlotta SacerdoteAnnemieke M W SpijkermanTammy Y N TongRosario TuminoKonstantinos K TsilidisJohn DaneshElio RiboliAdam S ButterworthClaudia LangenbergNita G ForouhiNicholas J WarehamPublished in: PLoS medicine (2020)
Our study found discordant associations of biochemically measured and genetically predicted differences in blood 25(OH)D with T2D risk. The findings based on MR analysis in a large sample of European ancestry do not support a causal association of total 25(OH)D or 25(OH)D metabolites with T2D and argue against the use of vitamin D supplementation for the prevention of T2D.