Therapeutic shutdown of HBV transcripts promotes reappearance of the SMC5/6 complex and silencing of the viral genome in vivo.

Lena AllweissKatja GierschAndrea PirosuTassilo VolzRobert C MuenchRudolf K BeranStephan UrbanHassan JavanbakhtSimon P FletcherMarc LütgehetmannMaura Dandri

Published in: Gut (2021)

These results reveal that therapeutics abrogating all HBV transcripts including HBx promote epigenetic suppression of the HBV minichromosome, whereas strategies protecting the human hepatocytes from reinfection are needed to maintain cccDNA silencing.

Keyphrases

hepatitis b virus
liver failure
endothelial cells
genome wide
dna methylation
sars cov
small molecule
gene expression
induced pluripotent stem cells
single cell
liver injury
drug induced