Melanocortin 1 receptor activation protects against alpha-synuclein pathologies in models of Parkinson's disease.

Waijiao CaiPranay SrivastavaDanielle FengYue LinCharles R VanderburgYuehang XuPamela McleanMatthew P FroschDavid E FisherMichael A SchwarzschildXiqun Chen

Published in: Molecular neurodegeneration (2022)

Our study supports an interaction between MC1R and αSyn that can be mediated by neuronal MC1R possibly through Nrf2. It provides evidence for MC1R as a therapeutic target and a rationale for development of MC1R-activating strategies for PD.

Keyphrases

oxidative stress
signaling pathway
clinical trial
brain injury
cerebral ischemia