The second-generation antipsychotic drug aripiprazole modulates the serotonergic system in pancreatic islets and induces beta cell dysfunction in female mice.
Diana GrajalesPatricia VázquezMónica Ruíz-RosarioEva TuduríMercedes MirasierraVítor FerreiraAna Belén HitosDora KollerPablo ZubiaurJuan C CigudosaFrancisco Abad-SantosMario VallejoIván QuesadaBoaz TiroshGil LeibowitzÁngela M ValverdePublished in: Diabetologia (2021)
Both SGAs induced weight gain and beta cell dysfunction, leading to glucose intolerance; however, aripiprazole had a more potent effect in terms of metabolic alterations, which was likely a result of its ability to modulate the serotonergic system. The deleterious metabolic effects of SGAs on islet function should be considered while treating patients as these drugs may increase the risk for development of the metabolic syndrome and diabetes.
Keyphrases
- weight gain
- metabolic syndrome
- single cell
- end stage renal disease
- body mass index
- type diabetes
- oxidative stress
- ejection fraction
- newly diagnosed
- cardiovascular disease
- chronic kidney disease
- birth weight
- drug induced
- prognostic factors
- stem cells
- blood glucose
- diabetic rats
- emergency department
- weight loss
- insulin resistance
- glycemic control
- anti inflammatory
- mesenchymal stem cells
- electronic health record
- stress induced