Potential of Polyphenols to Restore SIRT1 and NAD+ Metabolism in Renal Disease.
Claudia Tovar-PalacioLilia G NoriegaAdriana MercadoPublished in: Nutrients (2022)
SIRT1 is an NAD + -dependent class III histone deacetylase that is abundantly expressed in the kidney, where it modulates gene expression, apoptosis, energy homeostasis, autophagy, acute stress responses, and mitochondrial biogenesis. Alterations in SIRT1 activity and NAD + metabolism are frequently observed in acute and chronic kidney diseases of diverse origins, including obesity and diabetes. Nevertheless, in vitro and in vivo studies and clinical trials with humans show that the SIRT1-activating compounds derived from natural sources, such as polyphenols found in fruits, vegetables, and plants, including resveratrol, quercetin, and isoflavones, can prevent disease and be part of treatments for a wide variety of diseases. Here, we summarize the roles of SIRT1 and NAD + metabolism in renal pathophysiology and provide an overview of polyphenols that have the potential to restore SIRT1 and NAD + metabolism in renal diseases.
Keyphrases
- oxidative stress
- ischemia reperfusion injury
- gene expression
- clinical trial
- liver failure
- histone deacetylase
- type diabetes
- cell death
- cardiovascular disease
- endoplasmic reticulum stress
- dna methylation
- respiratory failure
- drug induced
- insulin resistance
- drinking water
- skeletal muscle
- risk assessment
- physical activity
- glycemic control
- aortic dissection
- study protocol
- body mass index
- cell proliferation
- health risk
- acute respiratory distress syndrome
- pi k akt