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ADAM33's Role in Asthma Pathogenesis: An Overview.

Jakub SleziakAntoni GaworMarta BłażejewskaKatarzyna AntoszKrzysztof Gomułka
Published in: International journal of molecular sciences (2024)
Asthma is a complex chronic respiratory disease characterized by airway hyperresponsiveness, inflammation, and obstruction. Many genes have been identified as associated with asthma but none with such substantial significance as the ADAM33 gene due to its role in airway remodeling and bronchial hyperresponsiveness. This review summarizes the current knowledge on the genetic and functional aspects of ADAM33 in asthma pathogenesis. We highlight its genetic variants associated with asthma susceptibility and severity, as well as the functional effects of ADAM33 on airway remodeling, smooth muscle cell proliferation, and its interplay with environmental factors. Additionally, we discuss the potential clinical implications of ADAM33 as a therapeutic target for asthma management.
Keyphrases
  • chronic obstructive pulmonary disease
  • lung function
  • allergic rhinitis
  • smooth muscle
  • cell proliferation
  • genome wide
  • healthcare
  • cystic fibrosis
  • copy number
  • risk assessment
  • cell cycle
  • signaling pathway